{"Absorption, Distribution and Excretion":"In rats receiving (14)C benzyl chloride in corn oil by gavage, the peak plasma level was reached after 30 min. The distribution half-life was 1.3 hr, while the elimination half-life was 58.5 hr. After 48 hr, the higher concentrations were found in the stomach, gastric contents, ileum and duodenum, followed by liver, adrenal, bone marrow and blood. After 72 hr, approximately 76% was excreted in urine and, in expired air, 7% as (14)CO2 and less than 1.3% as benzyl chloride or its metabolites.","Adverse Effects":"Neurotoxin - Other CNS neurotoxin","Aliases":["Benzyl Chloride","Benzyl chloride","(Chloromethyl)benzene","100-44-7","Chloromethylbenzene","α-Chlorotoluene","Benzylchloride","Benzylchlorid","Chlorophenylmethane","Tolyl chloride","Chlorure de benzyle","α-Chlortoluol","omega-Chlorotoluene","Benzene, (chloromethyl)-","RCRA waste number P028","Toluene, α-chloro-","NCI-C06360","Benzile","Benzyle","Phenylmethyl chloride","Dtxsid0020153","AI3-15518","83H19HW7K6","NSC-8043","Dtxcid00153","Chebi:615597","Chebi:23156","202-853-6","905-236-6","Benzene, chloromethyl-","1-(chloromethyl)benzene","NSC 8043","chloromethyl-benzene","Mfcd00000889",".omega.-Chlorotoluene","a-Chlorotoluene","33712-34-4","1-chloromethylbenzene","benzyl-chloride","CCRIS 79","HSDB 368","Toluene, ar-chloro-","(Chloromethyl)-benzene","Einecs 202-853-6","UN1738","RCRA waste no. P028","Benzylchloride; Chloromethylbenzene; α-Chlorotoluene","benzyi chloride","benzyl choride","Unii-83h19hw7k6","BnCl","α-chloro-toluene","Benzile(cloruro di)","PhCH2Cl","Benzyle(chlorure de)","C6H5CH2Cl","Benzyl-?,?-d2 chloride","Benzyl Alcohol Impurity 2","Ec 202-853-6","Toluene,α-chloro","Schembl7413","WLN: G1R","Schembl59637","Benzyl chloride, unstabilized","Schembl116833","Schembl134463","Schembl597661","Schembl942049","Benzene, (chloromethyl)- (VA","Chembl498878","Schembl1616642","Benzyl chloride, AR, \u003e=99%","Schembl15899384","Schembl20994000","NSC8043","IBA71234","TCA66111","Tox21_200266","SBB040645","Akos000118784","Msk000015-100a","UN 1738","Benzyl chloride [UN1738] ","Ncgc00090818-01","Ncgc00090818-02","Ncgc00257820-01","Cas-100-44-7","Benzyl chloride, purum, \u003e=99.0%","DB-058434","B0412","Benzyl chloride, puriss., \u003e=99.5%","NS00010722","ST50214092","C19167","Benzylchloride Solution in Acetonitrile, 100ug/mL","F106800","Q412260","Benzalkonium chloride impurity c","Benzalkonium chloride solution Impurity C","Benzyl chloride, unstabilized [UN1738] ","InChI=1/C7H7Cl/c8-6-7-4-2-1-3-5-7/h1-5H,6H","Racecadotril Impurity J; Benzalkonium EP Chloride Impurity C","Benzyl chloride, ReagentPlus(R), 99%, contains \u003c=1% propylene oxide as stabilizer","9CL"],"Biological Half-Life":"Whole body (animal studies): 2-3 days; [TDR, p. 177]","Boiling Point":"354 °","CAS":"100-44-7","Chemical Classes":"Hazardous Air Pollutants (HAPs)","ChemicalClasses":[],"Chirality":"achiral","Classes":["Lachrymator","Carcinogen"],"Color/Form":"Colorless to slightly yellow liquid","Decomposition":"When heated to decomposition it emits toxic fumes of /hydrogen chloride/.","Density":"1.1 at 68 °F (EPA, 1998) - Denser than water; will sink g/cm\u003csup\u003e3\u003c/sup\u003e","Ecotoxicity Values":"LC50; Species: Penaeus setiferus (white shrimp); Conditions: /static/; Concentration: 7.1 mg/L for 24 hr","Esters":[],"European Community (EC) Number":"905-236-6","Flash Point":"153 °F (EPA, 1998)","Formating":[],"HMDB ID":"HMDB0059882","HeavyAtomCount":8,"IUPACName":"chloromethylbenzene","Impurities":"Benzyl chloride is sold in two quality grades, identified as ''benzyl chloride, pure'' and ''benzyl chloride, pure and stabilized''. Their assay is in both cases \u003e 99 %. Impurities include benzal chloride, toluene, chlorotoluene, chlorobenzene, and hydrogen chloride.","InChI":"InChI=1S/C7H7Cl/c8-6-7-4-2-1-3-5-7/h1-5H,6H2","InChIKey":"KCXMKQUNVWSEMD-UHFFFAOYSA-N","MeSH Headers":[{"Id":"M0075970","Link":"https://id.nlm.nih.gov/mesh/M0075970.html","Name":"benzyl chloride","Ref":96},{"Id":"DescTree","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":"MeSH Tree","Ref":98},{"Id":"PubMed from MeSH","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":null,"Ref":118}],"Melting Point":"-54 to -45 °F (EPA, 1998)","Metabolism/Metabolites":"Benzyl chloride ... and other compounds with labile halogen atom give mercapturic acids /benzylmercapturic acid/ in which the l-acetylcysteine moiety replaces the labile halogen.","MolecularFormula":"C\u003csub\u003e7\u003c/sub\u003eH\u003csub\u003e7\u003c/sub\u003eCl","MolecularWeight":"126.58 g/mol","Non-Human Toxicity Values":"LD50 Mouse oral 1500 mg/kg","Odor":"Rather unpleasant, irritating odor","Physical Description":"Benzyl chloride appears as a colorless liquid with an irritating odor. Toxic by inhalation and skin absorption. Flash point 153 °F. Slightly soluble in water. Corrosive to metals and tissue. A lachrymator. Density 9.2 lb /gal.","PubChemId":7503,"Records":{"UNII":{"Impurities":[]}},"RefChem":"6392","RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Benzyl_chloride","Name":"Benzyl chloride","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q412260","Name":"Benzyl chloride","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/7503","Name":"Benzyl chloride","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=100-44-7","Name":"Benzyl chloride","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0059882","Name":"Benzyl chloride","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C19167","Name":"Benzyl chloride","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/83H19HW7K6","Name":"Benzyl chloride","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020153","Name":"Benzyl chloride","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 7503, Benzyl Chloride. Accessed March 27, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/7503\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/7503\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Benzyl chloride. UNII: 83H19HW7K6. Global Substance Registration System. Accessed March 27, 2026. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/83H19HW7K6\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/83H19HW7K6\u003c/a\u003e"],"SMILES":"C1=CC=C(C=C1)CCl","SaltData":[],"Salts":[],"Solubility":"Reaction (NTP, 1992)","Stability/Shelf Life":"Stablity during transport: stable","StereoisomerData":[],"Stereoisomers":[],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 59.168 32.556\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#1ff01f\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h60v33H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m58.125 23.894.005-15.24M55.687 22.486l.004-12.424\"/\u003e\u003c/g\u003e\u003cpath d=\"M58.13 8.654 44.939 1.038\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M44.939 1.038 31.743 8.662M44.94 3.854 34.181 10.07\"/\u003e\u003c/g\u003e\u003cpath d=\"m31.743 8.662-.005 15.24\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m31.738 23.902 13.191 7.616M34.177 22.495l10.752 6.207\"/\u003e\u003c/g\u003e\u003cpath d=\"m58.125 23.894-13.196 7.624M31.743 8.662 18.552 1.047M18.552 1.047 6.875 7.789\" class=\"bond\"/\u003e\u003cpath stroke=\"none\" d=\"M2.906 6.847q-.786 0-1.239.53-.452.523-.452 1.446 0 .911.417 1.447.422.53 1.268.53.321 0 .607-.054.291-.059.565-.143v.536q-.274.101-.565.149-.292.053-.697.053-.744 0-1.25-.309-.5-.31-.75-.875-.25-.572-.25-1.34 0-.744.268-1.309.274-.566.804-.882.529-.321 1.279-.321.78 0 1.352.286l-.244.524q-.226-.102-.506-.185-.274-.083-.607-.083m2.756 4.423h-.601V6.055h.601z\" class=\"atom\"/\u003e\u003cpath stroke=\"#1ff01f\" d=\"m6.875 7.789 5.838-3.371\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Subjective Effects":null,"Title":"Benzyl chloride","Toxicity Data":"LC50 (rat) = 150 ppm/2H","UNII":"83H19HW7K6","Wikidata":"Q412260","Wikipedia":"Benzyl_chloride","XLogP":2.3}